Structure of PDB 8w5z Chain C

Receptor sequence

>8w5zC (length=333) Species: 6944 (Ixodes)

NFTYVSPDRYVLGPDSRRYPYNNDMPLIFIGGMPRSGTTLVRVLLDAHPD
VRCGEETRVIPRLLSLKQQWVKNPTEMHRLLEGGITDEVLDAAMSAFILE
VIVRHGKPAPRLCNKDPFTLRAAVYLHRLFPRAKFLLMIRDGRAVVHSII
TRKVTITGYDLSDYRQCLKRWNAAMTSMYAQCQQLGPGLCLPVYYEQLVL
HPRAWMQRILAFLEVPWNDSVLHHEQLINQSGIALSKLERSTDQVIKPIN
LGALSKWVGHIPEDVVRDMAKVAPMLAQLGYDPAANPPDYGQPDNFVLNN
TLEIKKKMEEWQARERELEEHRELIKQSIAKKK

3D structure

• PDB: 8w5z Crystal structure of tick tyrosylprotein sulfotransferase reveals the activation mechanism of the tick anticoagulant protein madanin.
• Chain: C
• Resolution: 1.55 Å

Enzymatic activity

• Enzyme Commision number: 2.8.2.20: protein-tyrosine sulfotransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	E115 R118	E76 R79
BS02	peptide	C	P73 E95 R97 R101 P156 F157 R160 V193 T194 I195 T196 Y198	P34 E56 R58 R62 P117 F118 R121 V154 T155 I156 T157 Y159
BS03	A3P	C	R74 S75 G76 T77 T78 R179 S187 R191 Y234 S280 Q283 V284 P287 N289 A292 K295	R35 S36 G37 T38 T39 R140 S148 R152 Y195 S241 Q244 V245 P248 N250 A253 K256

Gene Ontology

Molecular Function

• GO:0008476 protein-tyrosine sulfotransferase activity

Biological Process

• GO:0006478 peptidyl-tyrosine sulfation

External links

• PDB: RCSB:8w5z, PDBe:8w5z, PDBj:8w5z
• PDBsum: 8w5z
• PubMed: 38354785
• UniProt: B7Q097