Structure of PDB 8w5s Chain C

Receptor sequence

>8w5sC (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]

IRDAEILRKAMKGFGTDEQAIVDVVANRSNDQRQKIKAAFKTSYGKDLIK
DLKSELSGNMEELILALFMPPTYYDAWSLRKAMQGAGTQERVLIEILCTR
TNQEIREIVRCYQSEFGRDLEKDIRSDTSGHFERLLVSMCQGNRDENQSI
NHQMAQEDAQRLYQAGEGRLGTDESCFNMILATRSFPQLRATMEAYSRMA
NRDLLSSVSREFSGYVESGLKTILQCALNRPAFFAERLYYAMKGAGTDDS
TLVRIVVTRSEIDLVQIKQMFAQMYQKTLGTMIAGDTSGDYRRLLLAIVG
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3D structure

PDB

8w5s structure dissection of the membrane aggregation mechanism induced by Annexin A7 mutation

Chain

Resolution

2.1162 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	C	D306 E308	D119 E121
BS02	CA	C	M429 G431 G433 D473	M242 G244 G246 D286
BS03	CA	C	K240 L243 E248	K53 L56 E61
BS04	CA	C	M198 G200 F201 G202 E242	M11 G13 F14 G15 E55
BS05	CA	C	R189 D190	R2 D3
BS06	CA	C	M270 G272 G274 D314	M83 G85 G87 D127
BS07	CA	C	R312 T315 E320	R125 T128 E133
BS08	CA	C	S316 G317 H318 F319	S129 G130 H131 F132
BS09	CA	C	S396 F399 E404	S209 F212 E217
BS10	CA	C	G353 R356 G358 E398	G166 R169 G171 E211
BS11	CA	C	T434 D436	T247 D249

External links

PDB	RCSB:8w5s, PDBe:8w5s, PDBj:8w5s
PDBsum	8w5s
PubMed
UniProt	P20073\|ANXA7_HUMAN Annexin A7 (Gene Name=ANXA7)

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