Structure of PDB 8w1h Chain C

Receptor sequence

>8w1hC (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]

LIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWE
LDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALD
FNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEEN
ELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFI
RIQAKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMI
YFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSGYHYLRS
TVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKF

3D structure

PDB

8w1h Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.

Chain

Resolution

2.1 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HEM	C	F72 H76 Y79 S151 G152 F153 F158 R159 Y175 W324 H328 V332 Y350 L351	F33 H37 Y40 S112 G113 F114 F119 R120 Y136 W279 H283 V287 Y297 L298
BS02	ZIQ	C	R103 E105 W208 R211 T212 P213 F304	R64 E66 W169 R172 T173 P174 F259
BS03	A1AEY	C	F72 H76 F140 P149 A150	F33 H37 F101 P110 A111
BS04	A1AEY	C	Y42 Y45	Y3 Y6

External links

PDB	RCSB:8w1h, PDBe:8w1h, PDBj:8w1h
PDBsum	8w1h
PubMed	39106326
UniProt	P48775\|T23O_HUMAN Tryptophan 2,3-dioxygenase (Gene Name=TDO2)

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