Structure of PDB 8w0l Chain C

Receptor sequence
>8w0lC (length=582) Species: 5476 (Candida albicans) [Search protein sequence]
QTHNVVHEANGVKLRETPKEFFERQPNKGHIHDVNQYKQMYEQSIKDPQG
FFGPLAKELLSWDHDFHTVKSGTLKNGDAAWFLGGELNASYNCVDRHAFA
NPDKPALICEADDEKDSHILTYGDLLREVSKVAGVLQSWGIKKGDTVAVY
LPMNAQAIIAMLAIARLGAAHSVIFAGFSAGSIKDRVNDASCKALITCDE
GKRGGRTTNIKKLCDEALVDCPTVEKVLVYKRTNNPEIHLTEGRDYYWDV
ETAKFPGYLPPVSVNSEDPLFLLYTSGSTGTPKGVVHSTAGYLLGAALST
KYIFDIHPEDILFTAGDVGWITGHTYALYGPLLLGVPTIIFEGTPAYPDY
GRFWQIVEKHKATHFYVAPTALRLLRKAGEQEIAKYDLSSLRTLGSVGEP
ISPDIWEWYNEFVGKNQCHISDTYWQTESGSHLIAPLAGVVPNKPGSASY
PFFGIDAALIDPVTGVEIEGNDAEGVLAIKDHWPSMARTVYKNHTKYMDT
YMNPYPGYYFTGDGAARDHDGYYWIRGRVDDVVNVSGHRLSTAEIEAALI
EDKKVSEAAVVGIHDDITGQLVLQVRKTIGPF
3D structure
PDB8w0l Crystal structure of Acetyl-CoA synthetase 2 from Candida albicans in complex with a propyne AMP ester inhibitor and CoA
ChainC
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.2.1.1: acetate--CoA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YHT C I340 G417 E418 P419 D441 T442 Y443 W444 Q445 T446 D532 I544 R547 R558 I321 G398 E399 P400 D422 T423 Y424 W425 Q426 T427 D513 I525 R528 R539
BS02 COA C F194 R222 R618 F624 F175 R203 R576 F582
Gene Ontology
Molecular Function
GO:0003987 acetate-CoA ligase activity
GO:0005524 ATP binding
GO:0016208 AMP binding
GO:0016874 ligase activity
Biological Process
GO:0019427 acetyl-CoA biosynthetic process from acetate

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Molecular Function
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Biological Process
External links
PDB RCSB:8w0l, PDBe:8w0l, PDBj:8w0l
PDBsum8w0l
PubMed
UniProtQ8NJN3|ACS2_CANAL Acetyl-coenzyme A synthetase 2 (Gene Name=ACS2)

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