Structure of PDB 8vy3 Chain C

Receptor sequence
>8vy3C (length=1057) Species: 9606 (Homo sapiens) [Search protein sequence]
EQVFHFYWLDAYEDQYNQPGVVFLFGKVWIESAETHVSCCVMVKNIERTL
YFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEK
NYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTNTSSLELF
LMNRKIKGPCWLEVKSPQLLNQPVSWCKAEAMALKPDLVNVIKDVSPPPL
VVMAFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVS
KPKDCIFPYAFKEVIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGH
NIYGFELEVLLQRINVCKAPHWSKIGRLKRSNMPKGERNATCGRMICDVE
ISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYSESSQLLYLLEH
TWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLH
AFYENNYIVPDKQIGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFT
TVQRVIPELPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQY
DIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTYKGREILMHTKEMVQ
KMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLLEIDIDG
VFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTG
NFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKD
PQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRA
YAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLD
PTQFRVHHYHKDEENDQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGS
GTDMEPSLYRCSNIDCKASPLTFTVQLSNKLIMDIRRFIKKYYDGWLICE
EPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIF
DAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQFLSRSGYSEV
NLSKLFA
3D structure
PDB8vy3 Human PRC2 - AavLEA1 (1:40 molar ratio)
ChainC
Resolution2.98 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C1283 C1286 C1310 C1315 C884 C887 C911 C916
BS02 ZN C C1348 C1353 C1371 C949 C954 C972
External links
PDB RCSB:8vy3, PDBe:8vy3, PDBj:8vy3
PDBsum8vy3
PubMed
UniProtP09884|DPOLA_HUMAN DNA polymerase alpha catalytic subunit (Gene Name=POLA1)

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