Structure of PDB 8vph Chain C

Receptor sequence

>8vphC (length=537) Species: 1496 (Clostridioides difficile) [Search protein sequence]

GIYYTPKIIVDYIVKKTLKNHDIIKNPYPRILDISCGCGNFLLEVYDILY
DLFEENIYELKKKYDENYWTVDNIHRHILNYCIYGADIDEKAISILKDSL
TNKNLFCCDSLKKKWRYKFDYIVGNPPYIGHKKLEKKYKKFLLEKYSEVY
KDKADLYFCFYKKIIDILKQGGIGSVITPRYFLESLSGKDLREYIKSNVN
VQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYIDVFKIKNEDICINKF
ETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYNKIQEKCKYSLED
IAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIKSKNINKYIVDKS
EYRLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECKSGIRKWYELQWG
REKLFFERKKIMYPYKSNENRFAIDYDNNFSSADVYSFFIKEEYLDKFSY
EYLVGILNSSVYDKYFKITAKKMSKNIYDYYPNKVMKIRIFRDNNYEEIE
NLSKQIISILLNKSIDKGKVEKLQIKMDNLIMDSLGI

3D structure

PDB

8vph Quinoline-based compounds can inhibit diverse enzymes that act on DNA

Chain

Resolution

3.18 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	C	Y30 Y168 H171 K193 Y221 S227 F253 I256 G257 F345 Q346 R432 W439 R441 K456 Y476 K511 M513 S514 Y521 P522 N523	Y3 Y128 H131 K153 Y181 S187 F213 I216 G217 F305 Q306 R392 W399 R401 K416 Y436 K471 M473 S474 Y481 P482 N483
BS02	dna	C	H171 K172 K176 K179 D192 K193 I349 C352 D353 K378 K380 R425 Q438 W439 Y455 K456 K515	H131 K132 K136 K139 D152 K153 I309 C312 D313 K338 K340 R385 Q398 W399 Y415 K416 K475
BS03	Q8Y	C	D114 D149 S150 P167 Y178 L196 F200	D87 D109 S110 P127 Y138 L156 F160

External links

PDB	RCSB:8vph, PDBe:8vph, PDBj:8vph
PDBsum	8vph
PubMed
UniProt	A0A031WG99

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