Structure of PDB 8vpg Chain C

Receptor sequence

>8vpgC (length=537) Species: 1496 (Clostridioides difficile) [Search protein sequence]

GIYYTPKIIVDYIVKKTLKNHDIIKNPYPRILDISCGCGNFLLEVYDILY
DLFEENIYELKKKYDENYWTVDNIHRHILNYCIYGADIDEKAISILKDSL
TNKNLFCCDSLKKKWRYKFDYIVGNPPYIGHKKLEKKYKKFLLEKYSEVY
KDKADLYFCFYKKIIDILKQGGIGSVITPRYFLESLSGKDLREYIKSNVN
VQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYIDVFKIKNEDICINKF
ETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYNKIQEKCKYSLED
IAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIKSKNINKYIVDKS
EYRLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECKSGIRKWYELQWG
REKLFFERKKIMYPYKSNENRFAIDYDNNFSSADVYSFFIKEEYLDKFSY
EYLVGILNSSVYDKYFKITAKKMSKNIYDYYPNKVMKIRIFRDNNYEEIE
NLSKQIISILLNKSIDKGKVEKLQIKMDNLIMDSLGI

3D structure

PDB

8vpg Quinoline-based compounds can inhibit diverse enzymes that act on DNA

Chain

Resolution

3.05 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	C	Y30 N165 Y168 H171 K173 K193 Y221 S227 F253 I256 G257 Q346 R432 W439 R441 K456 Y476 K511 M513 S514 Y521 P522 N523	Y3 N125 Y128 H131 K133 K153 Y181 S187 F213 I216 G217 Q306 R392 W399 R401 K416 Y436 K471 M473 S474 Y481 P482 N483
BS02	dna	C	H171 K172 K179 D192 K193 I349 G351 C352 D353 K378 K380 R425 Q438 W439 Y455 K456 K515	H131 K132 K139 D152 K153 I309 G311 C312 D313 K338 K340 R385 Q398 W399 Y415 K416 K475

External links

PDB	RCSB:8vpg, PDBe:8vpg, PDBj:8vpg
PDBsum	8vpg
PubMed
UniProt	A0A031WG99

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