Structure of PDB 8vkb Chain C

Receptor sequence

>8vkbC (length=385) Species: 126793 (Plasmodium vivax Sal-1) [Search protein sequence]

PDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYV
CDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTW
HIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLA
PVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIG
FSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQF
NLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGND
KYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSV
FEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL

3D structure

PDB

8vkb Exploring Subsite Selectivity within Plasmodium vivax N -Myristoyltransferase Using Pyrazole-Derived Inhibitors.

Chain

Resolution

2.43 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MYA	C	Y28 K29 F30 W31 Y95 V96 L163 V165 R170 S171 R173 A175 P176 T183 I186 W192 Q193 A194 Y196 T197 L202 Y393	Y3 K4 F5 W6 Y70 V71 L138 V140 R145 S146 R148 A150 P151 T158 I161 W167 Q168 A169 Y171 T172 L177 Y368
BS02	A1AB8	C	V96 E97 D98 F103 R104 F105 Y211 S319 Y334 N365 L367 L410	V71 E72 D73 F78 R79 F80 Y186 S294 Y309 N340 L342 L385

Gene Ontology

	Molecular Function
GO:0004379	glycylpeptide N-tetradecanoyltransferase activity
GO:0016746	acyltransferase activity
GO:0046872	metal ion binding

	Biological Process
GO:0018008	N-terminal peptidyl-glycine N-myristoylation

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8vkb, PDBe:8vkb, PDBj:8vkb
PDBsum	8vkb
PubMed	38680035
UniProt	A5K1A2

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