Structure of PDB 8v4x Chain C

Receptor sequence

>8v4xC (length=361) Species: 9606 (Homo sapiens)

QPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDL
TEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRS
ENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANI
VFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDM
GKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHEL
PESMCLKIQLGFAAEFSNVMIIYTSIVPEIIMCDAYVTDFPLDLDIDPKD
ANKGTPEETGSYLHCLYTRLSSLQKLKEHLVFTVCLSYQYLEDTVEDKQE
VNVGKPLIAKL

3D structure

• PDB: 8v4x Inhibition of MALT1 and BCL2 induces synergistic anti-tumor activity in models of B cell lymphoma.
• Chain: C
• Resolution: 2.486 Å

Enzymatic activity

• Enzyme Commision number: 3.4.22.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	L359 D365 A413 H415 D462 C464 E497 A498 F499 E500 I501 Q502 H503 L541 K545	L23 D29 A77 H79 D126 C128 E161 A162 F163 E164 I165 Q166 H167 L205 K209
BS02	A1AAB	C	V344 A345 L346 K379 V381 L383 E390 N393 A394 E397 F398 L401 W580 Q676 I712 L715	V8 A9 L10 K43 V45 L47 E54 N57 A58 E61 F62 L65 W244 Q324 I358 L361

Gene Ontology

Molecular Function

• GO:0004197 cysteine-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:8v4x, PDBe:8v4x, PDBj:8v4x
• PDBsum: 8v4x
• PubMed: 38507740
• UniProt: Q9UDY8|MALT1_HUMAN Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Gene Name=MALT1)