Structure of PDB 8uvp Chain C

Receptor sequence

>8uvpC (length=555) Species: 9606 (Homo sapiens)

ESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYG
PPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEK
NAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMA
ATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVD
LEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSL
AVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQY
PVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGP
ELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGG
AADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYI
PLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRAC
KLAIRESIESEIRRERERQDPVPEIRRDHFEEAMRFARRSVSDNDIRKYE
MFAQT

3D structure

• PDB: 8uvp Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors.
• Chain: C
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	C	I206 T249 G250 K251 T252 L253 I380 H384 G408 A409	I11 T54 G55 K56 T57 L58 I185 H189 G213 A214
BS02	ADP	C	I479 G521 G523 K524 T525 D577 I656	I284 G326 G328 K329 T330 D382 I461
BS03	XO8	C	L492 V493 P496 V497 P510 K512 P571 K615 N616	L297 V298 P301 V302 P315 K317 P376 K420 N421

External links

• PDB: RCSB:8uvp, PDBe:8uvp, PDBj:8uvp
• PDBsum: 8uvp
• PubMed: 39122922
• UniProt: P55072|TERA_HUMAN Transitional endoplasmic reticulum ATPase (Gene Name=VCP)