Structure of PDB 8uvm Chain C

Receptor sequence
>8uvmC (length=316) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
SNAEVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPH
NSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQ
VNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANF
CALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQT
TLKGVEAVMYMGTLSYEQFKKGVQPCTCGKQATKYLVQQESPFVMMSAPP
AQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKG
PITDVFYKENSYTTTI
3D structure
PDB8uvm Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model
ChainC
Resolution2.85 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y3R C W106 N109 C111 L162 G163 D164 M208 P248 Y264 Y268 Q269 G271 H272 Y273 W109 N112 C114 L165 G166 D167 M211 P250 Y266 Y270 Q271 G273 H274 Y275
BS02 ZN C C189 C224 C226 C192 C226 C228
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8uvm, PDBe:8uvm, PDBj:8uvm
PDBsum8uvm
PubMed38547259
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

[Back to BioLiP]