Structure of PDB 8umy Chain C

Receptor sequence
>8umyC (length=325) Species: 9606 (Homo sapiens) [Search protein sequence]
KIRNLPWVEKYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLYGPPGTG
KTSTILACAKQLYKDKEFGSMVLELNASDDRGIDIIRGPILSFASTRTIF
KKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPAL
QSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRR
ALNILQSTNMAFGKVTEETVYTCTGHPLKSDIANILDWMLNQDFTTAYRN
ITELKTLKGLALHDILTEIHLFVHRVDFPSSVRIHLLTKMADIEYRLSVG
TNEKIQLSSLIAAFQVTRDLIVAEA
3D structure
PDB8umy Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC.
ChainC
Resolution2.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C G97 I98 R102 T131 G82 I83 R87 T116
BS02 AGS C R139 R168 R124 R153
BS03 AGS C V23 Y26 R27 L34 I35 G63 T64 G65 K66 T67 S68 N156 M213 R214 V8 Y11 R12 L19 I20 G48 T49 G50 K51 T52 S53 N141 M198 R199
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0019899 enzyme binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0032508 DNA duplex unwinding
GO:1900264 positive regulation of DNA-directed DNA polymerase activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005663 DNA replication factor C complex
GO:0031390 Ctf18 RFC-like complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8umy, PDBe:8umy, PDBj:8umy
PDBsum8umy
PubMed38669181
UniProtP40937|RFC5_HUMAN Replication factor C subunit 5 (Gene Name=RFC5)

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