Structure of PDB 8uh6 Chain C

Receptor sequence
>8uh6C (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRD
VSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLM
VWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDV
KSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVR
ESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLN
MRKYRMGLIQTPDQLRFSYMAIIEGAK
3D structure
PDB8uh6 Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex.
ChainC
Resolution3.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WO8 C R26 N27 S29 D50 Y54 K122 D182 G221 M256 Q260 R26 N27 S29 D50 Y54 K122 D182 G221 M256 Q260
External links
PDB RCSB:8uh6, PDBe:8uh6, PDBj:8uh6
PDBsum8uh6
PubMed39152201
UniProtP17706|PTN2_HUMAN Tyrosine-protein phosphatase non-receptor type 2 (Gene Name=PTPN2)

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