Structure of PDB 8ufr Chain C

Receptor sequence
>8ufrC (length=401) Species: 9606 (Homo sapiens) [Search protein sequence]
FPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPAPEQLLSQARD
FINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWR
NAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAIT
VFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGW
TPGNGRFDVLPLLLQAPDEPPELFLLPPELVLEVPLEHPTLEWFAALGLR
WYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDV
AVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMK
HLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDP
W
3D structure
PDB8ufr Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase.
ChainC
Resolution1.871 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.39: nitric-oxide synthase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM C W178 C184 F353 W356 E361 F473 Y475 W99 C105 F274 W277 E282 F394 Y396
BS02 H4B C S102 R365 A446 W447 S35 R286 A367 W368
BS03 WK2 C V336 E361 V257 E282
BS04 ZN C C94 C99 C27 C32
BS05 H4B C W445 F460 E463 W366 F381 E384
Gene Ontology
Molecular Function
GO:0004517 nitric-oxide synthase activity
Biological Process
GO:0006809 nitric oxide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ufr, PDBe:8ufr, PDBj:8ufr
PDBsum8ufr
PubMed38417024
UniProtP29474|NOS3_HUMAN Nitric oxide synthase 3 (Gene Name=NOS3)

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