Structure of PDB 8ufq Chain C

Receptor sequence
>8ufqC (length=420) Species: 9606 (Homo sapiens) [Search protein sequence]
PRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPED
VATKDQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLK
DTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVK
YATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPA
NVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIR
HPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTQIGVRD
YCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVT
IVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLN
YRLTPSFEYQPDPWNTHVWK
3D structure
PDB8ufq Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase.
ChainC
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.39: nitric-oxide synthase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM C W414 R419 C420 V421 L429 M575 F589 W592 Q597 F709 Y711 W112 R117 C118 V119 L127 M273 F287 W290 Q295 F407 Y409
BS02 H4B C S339 V682 W683 S37 V380 W381
BS03 ZN C C331 C336 C29 C34
BS04 H4B C F696 H697 Q698 F394 H395 Q396
Gene Ontology
Molecular Function
GO:0004517 nitric-oxide synthase activity
Biological Process
GO:0006809 nitric oxide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ufq, PDBe:8ufq, PDBj:8ufq
PDBsum8ufq
PubMed38417024
UniProtP29475|NOS1_HUMAN Nitric oxide synthase 1 (Gene Name=NOS1)

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