Structure of PDB 8udv Chain C

Receptor sequence
>8udvC (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
ELPADPKWELSRARLTLGKPLEGCFGQVVMAEAIGIDKDRAAKPVTVAVK
MLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLMEYA
AKGNLREFLRARRSGEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAA
RNVLVTEDNVMKIADFGLALPVKWMAPEALFDRVYTHQSDVWSFGVLLWE
IFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPS
QRPTFKQLVEDLDRVLTVT
3D structure
PDB8udv Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations.
ChainC
Resolution2.348 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WIQ C E480 C482 F483 V486 A506 K508 E525 M529 I539 M555 Y557 A558 G561 E565 L624 D635 E22 C24 F25 V28 A48 K50 E67 M71 I81 M97 Y99 A100 G103 E107 L154 D165
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8udv, PDBe:8udv, PDBj:8udv
PDBsum8udv
PubMed38267212
UniProtP22607|FGFR3_HUMAN Fibroblast growth factor receptor 3 (Gene Name=FGFR3)

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