Structure of PDB 8ucd Chain C

Receptor sequence
>8ucdC (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]
LFPQWHLPIKIAAIIASLTFLYTLLREVIHPLATSHQQYFYKIPILVINK
VLPMVSITLLALVYLPGVIAAIVQLHFPHWLDKWMLTRKQFGLLSFFFAV
LHAIYSLSYPMRRSYRYKLLNWAYQQVQQNKEDAWIEHDVWRMEIYVSLG
IVGLAILALLAVTSIPSVSDSLTWREFHYIQSKLGIVSLLLGTIHALIFA
WNKWIDIKQFVWYTPPTFMIAVFLPIVVLIFKSILFL
3D structure
PDB8ucd AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity Against Prostate Cancer.
ChainC
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LBN C L166 F170 I177 V235 L93 F97 I104 V162
BS02 LBN C A228 L232 A155 L159
BS03 FAD C V129 Y130 K162 G165 L233 Q254 V63 Y64 K89 G92 L160 Q181
BS04 HEM C K116 P119 H175 A176 S179 L227 H268 F272 T290 K50 P53 H102 A103 S106 L154 H195 F199 T217
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0052851 ferric-chelate reductase (NADPH) activity
Cellular Component
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0010008 endosome membrane
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:8ucd, PDBe:8ucd, PDBj:8ucd
PDBsum8ucd
PubMed37861452
UniProtQ9UHE8|STEA1_HUMAN STEAP1 protein (Gene Name=STEAP1)

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