Structure of PDB 8u6h Chain C

Receptor sequence
>8u6hC (length=531) Species: 11678 (Human immunodeficiency virus type 1 BH10) [Search protein sequence]
SPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGP
ENPYNTPVFIKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKS
VTVLDVGDAYFSVPLDEDFRKYTAFTIINYQYNVLPQGWKGSPAIFQSSM
TKILEPFAAQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGL
TTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEWTVNDIQKLVGKLNWA
SQIYPGIKVRQLSKLLRGALTEVIPLTEEAELELAENREPVHGVYYDPSK
DLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQ
KITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLV
KLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTT
NQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIE
QLIKKEKVYLAWVPAHKGIGGNEQVDKLVSA
3D structure
PDB8u6h Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase.
ChainC
Resolution2.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VVE C L100 K101 K102 K103 V106 Y181 G190 H235 P236 D237 Y318 L95 K96 K97 K98 V101 Y167 G176 H221 P222 D223 Y295
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8u6h, PDBe:8u6h, PDBj:8u6h
PDBsum8u6h
PubMed37883896
UniProtP03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)

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