Structure of PDB 8tv5 Chain C

Receptor sequence

>8tv5C (length=294) Species: 9606 (Homo sapiens) [Search protein sequence]

KEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGD
QDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAES
DLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRK
GFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATV
AGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQAC
SPGFFKFEASESPCLECPEHTLPSPEGATSCECEEGFFRMPCTL

3D structure

PDB

8tv5 Synthetic Antibodies targeting EPHA2 Induce Diverse Signaling-Competent Clusters with Differential Activation

Chain

Resolution

4.6 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	C	D148 E166	D122 E140

External links

PDB	RCSB:8tv5, PDBe:8tv5, PDBj:8tv5
PDBsum	8tv5
PubMed
UniProt	P29317\|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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