Structure of PDB 8tov Chain C

Receptor sequence
>8tovC (length=203) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
PIVQMVHQCISPRTLNAWVKVVEEKAFSPEVIPMFSALSCGATPQDLNTM
LNTVGGHQAAMQMLKETINEEAAEWDRLHPMREPRGSDIAGTTSTLQEQI
GWMTHNPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIRQGPKEPFRDYV
DRFYKTLRAEQASQEVKNAATETLLVQNANPDCKTILKALGGATLEEMMT
ACQ
3D structure
PDB8tov Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators.
ChainC
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J6U C Y169 R173 K182 N183 Y154 R158 K167 N168
BS02 J6U C N53 L56 N57 M66 Q67 K70 I73 N74 S102 A105 G106 T107 Y130 N48 L51 N52 M61 Q62 K65 I68 N69 S87 A90 G91 T92 Y115
Gene Ontology

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Biological Process
External links
PDB RCSB:8tov, PDBe:8tov, PDBj:8tov
PDBsum8tov
PubMed38054267
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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