Structure of PDB 8to4 Chain C

Receptor sequence
>8to4C (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
ALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAT
SPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDY
VREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHV
KITDFGVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIP
ASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFS
KMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEVDA
3D structure
PDB8to4 EGFR(T790M/V948R) in complex with the allosteric inhibitor FRF-06-057
ChainC
Resolution2.99 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C N842 D855 N141 D154
BS02 ANP C G719 G721 A722 V726 A743 K745 M790 L792 M793 R841 N842 L844 D855 G18 G20 A21 V25 A42 K44 M89 L91 M92 R140 N141 L143 D154
BS03 IXR C A743 K745 I759 A763 M766 C775 L777 L788 M790 D855 F856 A42 K44 I58 A62 M65 C74 L76 L87 M89 D154 F155
External links
PDB RCSB:8to4, PDBe:8to4, PDBj:8to4
PDBsum8to4
PubMed
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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