Structure of PDB 8to3 Chain C

Receptor sequence

>8to3C (length=295) Species: 9606 (Homo sapiens) [Search protein sequence]

ALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAK
ANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVRE
HKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKIT
DFGLAKLLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDG
IPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIE
FSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMVVDAD

3D structure

PDB

8to3 EGFR(T790M/V948R) in complex with LN5461

Chain

Resolution

2.49 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	C	N842 D855	N138 D151
BS02	ANP	C	L718 A722 V726 A743 K745 M793 C797 D837 R841 N842 L844 D855	L17 A21 V25 A42 K44 M89 C93 D133 R137 N138 L140 D151

External links

PDB	RCSB:8to3, PDBe:8to3, PDBj:8to3
PDBsum	8to3
PubMed
UniProt	P00533\|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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