Structure of PDB 8tf4 Chain C

Receptor sequence

>8tf4C (length=602) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]

DWEQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNDFQQRGAVGE
TALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNL
NLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR
LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEQSLELV
PNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDS
WGEELSFLELVVSSKKREARQILEQTPVKELVSFKWKKYGRPYFCVLASL
YILYMICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIR
LVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTILGGPFHVIIITYASL
VLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTIMIQKM
IFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFE
LFLTIIDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRV
AQERDELWRAQVVATTVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVEN
HH

3D structure

PDB

8tf4 Structural mechanism of TRPV5 inhibition by econazole.

Chain

Resolution

2.86 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CPL	C	I337 I341 I348 Y349	I302 I306 I313 Y314
BS02	ERG	C	F425 F456 V459 L460 T479 I482 Q483 I486	F390 F421 V424 L425 T444 I447 Q448 I451
BS03	ERG	C	M497 P527 F534	M462 P492 F499
BS04	CPL	C	F343 L373 Y377	F308 L338 Y342
BS05	ECN	C	M466 A469 F472 L475	M431 A434 F437 L440
BS06	CPL	C	C494 V499 L502 Y526 P527 L530	C459 V464 L467 Y491 P492 L495
BS07	ERG	C	I557 A561 I565	I522 A526 I530
BS08	ERG	C	C556 A560 I564	C521 A525 I529
BS09	ECN	C	W495 L496	W460 L461

Gene Ontology

	Molecular Function
GO:0005216	monoatomic ion channel activity
GO:0005261	monoatomic cation channel activity
GO:0005262	calcium channel activity
GO:0005516	calmodulin binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

	Biological Process
GO:0006811	monoatomic ion transport
GO:0006816	calcium ion transport
GO:0035809	regulation of urine volume
GO:0051289	protein homotetramerization
GO:0055074	calcium ion homeostasis
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0098703	calcium ion import across plasma membrane

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016324	apical plasma membrane

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8tf4, PDBe:8tf4, PDBj:8tf4
PDBsum	8tf4
PubMed	38141613
UniProt	Q9XSM3\|TRPV5_RABIT Transient receptor potential cation channel subfamily V member 5 (Gene Name=Trpv5)

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