Structure of PDB 8te3 Chain C

Receptor sequence
>8te3C (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
GSAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMV
KHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYE
GTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLES
NPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIA
KFSKVRTDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSCLARQR
LLGRSWSVPVIRHLFAPLKEYFACV
3D structure
PDB8te3 Crystal structure of the homo-tetrameric DNMT3A methyltransferase domain(R882C/R676K)
ChainC
Resolution3.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH C F640 D641 G642 I643 T645 S663 E664 V665 D686 V687 G707 R891 S892 W893 F15 D16 G17 I18 T20 S38 E39 V40 D61 V62 G82 R254 S255 W256
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8te3, PDBe:8te3, PDBj:8te3
PDBsum8te3
PubMed38600075
UniProtQ9Y6K1|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Gene Name=DNMT3A)

[Back to BioLiP]