Structure of PDB 8tdc Chain C

Receptor sequence
>8tdcC (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
QSMSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKM
GVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAG
VTISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRL
MEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLP
RRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESG
GFRSLLINAVEASCIRTRELQSMADQ
3D structure
PDB8tdc Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1)
ChainC
Resolution1.8 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI C G7 A8 G9 Q10 L11 P35 N56 A69 V70 K71 P72 I78 C95 A96 A97 T122 T124 G9 A10 G11 Q12 L13 P37 N58 A71 V72 K73 P74 I80 C97 A98 A99 T124 T126
BS02 GIW C G175 S176 G177 S178
Gene Ontology
Molecular Function
GO:0004735 pyrroline-5-carboxylate reductase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
Biological Process
GO:0006561 proline biosynthetic process
GO:0034599 cellular response to oxidative stress
GO:0051881 regulation of mitochondrial membrane potential
GO:0055129 L-proline biosynthetic process
GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tdc, PDBe:8tdc, PDBj:8tdc
PDBsum8tdc
PubMed39133178
UniProtP32322|P5CR1_HUMAN Pyrroline-5-carboxylate reductase 1, mitochondrial (Gene Name=PYCR1)

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