Structure of PDB 8t9g Chain C

Receptor sequence

>8t9gC (length=536) Species: 9606 (Homo sapiens) [Search protein sequence]

ACRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQR
RIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSW
SPLQQNFMVHGDRECGFINDEIFVELVNALGQYSDKIFEAISSMFPDKGT
AEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFC
RRCFKYDCFLHFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAA
LTPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKE
SSISNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGC
RCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGS
KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK
YMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGI
FAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP

3D structure

PDB

8t9g Activation of automethylated PRC2 by dimerization on chromatin

Chain

Resolution

6.2 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SAH	C	A627 W629 M667 S669 F691 A692 N693 H694 Y731 Y741 V742	A412 W414 M452 S454 F476 A477 N478 H479 Y516 Y526 V527

External links

PDB	RCSB:8t9g, PDBe:8t9g, PDBj:8t9g
PDBsum	8t9g
PubMed
UniProt	Q15910\|EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 (Gene Name=EZH2)

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