Structure of PDB 8t7d Chain C

Receptor sequence

>8t7dC (length=390) Species: 9606 (Homo sapiens) [Search protein sequence]

KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATN
DQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNIL
GGTVFREAIICKNIPRLVSGWVKPIIIGRHAATDFVVPGPGKVEITYTPS
DGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYL
STKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAM
KSEGGFIWACKGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQE
TSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTK
DLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL

3D structure

PDB

8t7d Mechanistic and Biostructural Studies of Mutant IDH1

Chain

Resolution

3.444 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZT3	C	R109 A111 L120 W124 I128 M291	R106 A108 L117 W121 I125 M267

External links

PDB	RCSB:8t7d, PDBe:8t7d, PDBj:8t7d
PDBsum	8t7d
PubMed
UniProt	O75874\|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (Gene Name=IDH1)

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