Structure of PDB 8t3k Chain C

Receptor sequence

>8t3kC (length=541) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168)

FSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAIDDMKAGA
FTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHL
LTMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFL
TMGFLISWKLTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRV
LESVSGVRVIRAYVQETNDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKL
LVGASYLIGLGYGAFLVFRNELTLGELVSFNVYLGMMIWPMFAIGELINV
MQRGNASLDRVNETLSYETDVTDPKQPADLKEPGDIVFSHVSFTYPNLQD
ISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGEGSITFSGVPIQQIP
LDRLRGWIGYVPQDHLLFSRTVKENILYAHFEKDLHMLPETMVGSGGQKQ
RISIARALMANPEILILDQSLSAVDAKTEAAIIKNIRENRKGKTTFILTH
RLSAVEHADLILVMDGGVIAERGTHQELLANNGWYREQYER

3D structure

• PDB: 8t3k Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
• Chain: C
• Resolution: 3.33 Å

Enzymatic activity

• Enzyme Commision number: 7.6.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	C	Y346 N353 S375 G376 K377 T378 Q419 Q500	Y345 N347 S369 G370 K371 T372 Q413 Q469

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0042626 ATPase-coupled transmembrane transporter activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0046677 response to antibiotic
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8t3k, PDBe:8t3k, PDBj:8t3k
• PDBsum: 8t3k
• PubMed: 37938578
• UniProt: O07550|YHEI_BACSU Probable multidrug resistance ABC transporter ATP-binding/permease protein YheI (Gene Name=yheI)