Structure of PDB 8sxn Chain C

Receptor sequence
>8sxnC (length=816) Species: 9606 (Homo sapiens) [Search protein sequence]
KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKESPIKME
LLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYL
FYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDE
LQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALE
KLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLF
TMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPLCA
HLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDC
EKFYSFIHMTFQEFFAAMYYLLELPSRDVTVLLENYGKFEKGYLIFVVRF
LFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLE
LFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESL
SLGFLHNSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPG
CNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLC
VGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGD
SGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL
RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQ
SLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALE
TLQEEKPELTVVFEPS
3D structure
PDB8sxn Cryo-EM structures of NLRP3 reveal its self-activation mechanism
ChainC
Resolution4.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7YN C A227 A228 R351 I411 T439 F575 R578 E629 Y632 A71 A72 R195 I255 T283 F396 R399 E450 Y453
BS02 ATP C Y168 T169 L171 G229 G231 T233 I234 E306 Y381 P412 W416 H522 Y36 T37 L39 G73 G75 T77 I78 E150 Y225 P256 W260 H358
External links
PDB RCSB:8sxn, PDBe:8sxn, PDBj:8sxn
PDBsum8sxn
PubMed
UniProtQ96P20|NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 (Gene Name=NLRP3)

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