Structure of PDB 8stt Chain C

Receptor sequence
>8sttC (length=544) Species: 11678 (Human immunodeficiency virus type 1 BH10) [Search protein sequence]
SPIETVPVKLKPGMDGPKVKQLTEEKIKALVEICTEMEKEGKISKIGPEN
PYNTPVFIKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSA
TVLDVGDAYFSVPLDEDFRKYTAFTISINIRYQYNVLPQGWKGSPAIFQS
SMTKILEPFAAQNPDIVICQYMDDLYVGSDLEIGQHRTKIEELRQHLLRW
GLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVG
KLNWASQIYPGIKVRQLSKLLRGTKALTEVIPLTEEAELELAENREILKE
PVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHT
NDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIP
EWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKG
RQKVVPLTNTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDK
SESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGI
3D structure
PDB8stt Exploring Novel HIV-1 Reverse Transcriptase Inhibitors with Drug Resistant Mutants: A Double Mutant Surprise.
ChainC
Resolution2.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C D443 D549 D431 D537
BS02 29T C L100 K101 K102 K103 V179 Y188 F227 W229 L234 H235 P236 Y318 L94 K95 K96 K97 V167 Y176 F215 W217 L222 H223 P224 Y306
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8stt, PDBe:8stt, PDBj:8stt
PDBsum8stt
PubMed37861472
UniProtP03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)

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