Structure of PDB 8srk Chain C

Receptor sequence
>8srkC (length=1071) Species: 946362 (Salpingoeca rosetta) [Search protein sequence]
VAAKTLLIENEDGKGSTRMEVQDFMKRFHMHASEDDKTGSPSTAWGTLRF
PTKEATAPYLRLSVNDDPEDALLFVKAMLAQKYGETYDRPSLILSVTGGA
RNFTLPPRLETAIAKGLRLAAQRTNAWVVTGGTNTGVMKLTGQIMEALSK
TQSHFIPPTIGIATYGVIIGGDDMTRGEPPKIGLEYEMHKKDPPKTTPLD
DNHNLFLLVDDGSTNKFGKEIKFRAAFENAAGQAFAAPVVTIVVQGGPGT
LGTALQAVRQGTPIVVVDGSGLAADVLAYAYNFMHNPLTRFKSYTIDDLR
QKVAQTFNPKSSQQLTNLLDSALECVQDPNLVVVYSLQESGIDEFDDCIL
KAIFSSQGKLGNKLKQAMYFDQLDVAKRALSEASKNGQHNEIAACINDNL
MAAMMHNKPHFVELYLGFDAKIYELKPSEEVAKTNITALDELPSFALAIE
ELYKREAKKPHSHVQRLVSLSNTDVLGRHYRLANTRAYNVLRMDQIFARL
VSKDFSVNRDFTIYDSKYDKVPGIQFRRTAQASHMLFLWAICLDRFRMAR
HFWLIGDQSIINALVASRILERLSTHRALQGPHLAEERAKMQHNAKKFEE
LAVGVLGECHGSDSHMASEMLHSKNDMFNKKNAINIAYDAKSLAFLSHPA
TQSVINADWYGHLKSVTSFWAVLFAFFFPFFVLPFINFSGAHRLRRKFAK
FYSAPYTRFISDLLSHFVLCVVTSYFVLDKLEDTISAIEWILLVWFVALL
LEELRQMIFCDGIAEYISDTWNRLDLIMITLFFVGFFTHASDPSNQDSKV
VSKGIHAFLVVVLWLRFMRYYALSKNLGPKLIMMMEMMKDVSTFVFLLLI
FLIGYGVAAQSLLSPDEDFSSRTFIGVLFRPYFQIYGELFLDDLNSEANC
LGDTPFTECSRETVRMVPFFLAVYILGSNVLLVNLLIAMFNDTYMKVQEA
AEDLWRKQNYELCAEYKDRPFLPAPFILLAHVHMLFMRLLRLCGVHTQEH
EKIQDDETKRKITTFEELNTDKFLRRWERERQEMLEARVKMTNDNVVQAM
GMMDQLLEHMISFRFSLDQQA
3D structure
PDB8srk Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
ChainC
Resolution4.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR C V942 L949 F976 Y979 V845 L852 F879 Y882
BS02 APR C G149 A151 R152 G182 T184 F268 G298 G300 T301 G98 A100 R101 G131 T133 F217 G247 G249 T250
BS03 CA C L621 G623 L554 G556
BS04 CLR C I902 F905 I805 F808
BS05 CLR C R1012 P1015 R915 P918
BS06 CLR C R1012 F1016 R915 F919
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8srk, PDBe:8srk, PDBj:8srk
PDBsum8srk
PubMed
UniProtF2UB89

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