Structure of PDB 8skr Chain C

Receptor sequence
>8skrC (length=402) Species: 9606 (Homo sapiens) [Search protein sequence]
ASSWWTHVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLP
SVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENSEVLKSGRFVT
VQTISGTGALRIGASFLQRFFKFSRDVFLPKPTWGNHTPIFRDAGMQLQG
YRYYDPKTCGFDFTGAVEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKE
IATVVKKRNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYA
KNMGLYGERVGAFTMVCKDADEAKRVESQLKILIRPMYSNPPLNGARIAA
AILNTPDLRKQWLQEVKVMADRIIGMRTQLVSNLKKEGSTHNWQHITDQI
GMFCFTGLKPEQVERLIKEFSIYMTKDGRISVAGVTSSNVGYLAHAIHQV
TK
3D structure
PDB8skr High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology.
ChainC
Resolution2.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.6.1.1: aspartate transaminase.
2.6.1.7: kynurenine--oxoglutarate transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP C S133 G134 T135 W162 N215 D243 A245 Y246 S276 K279 R287 S105 G106 T107 W134 N187 D215 A217 Y218 S248 K251 R259
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity
GO:0008483 transaminase activity
GO:0016212 kynurenine-oxoglutarate transaminase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006103 2-oxoglutarate metabolic process
GO:0006107 oxaloacetate metabolic process
GO:0006520 amino acid metabolic process
GO:0006531 aspartate metabolic process
GO:0006532 aspartate biosynthetic process
GO:0006533 aspartate catabolic process
GO:0006536 glutamate metabolic process
GO:0006869 lipid transport
GO:0009058 biosynthetic process
GO:0015908 fatty acid transport
GO:0019470 4-hydroxyproline catabolic process
GO:0019550 glutamate catabolic process to aspartate
GO:0045471 response to ethanol
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005886 plasma membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8skr, PDBe:8skr, PDBj:8skr
PDBsum8skr
PubMed37839702
UniProtP00505|AATM_HUMAN Aspartate aminotransferase, mitochondrial (Gene Name=GOT2)

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