Structure of PDB 8sj2 Chain C

Receptor sequence

>8sj2C (length=343) Species: 10090 (Mus musculus)

KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFPLSHFEVLS
ATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDI
ILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKQGETW
RLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQ
ELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTE
KLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK

3D structure

• PDB: 8sj2 Structure of ternary complex of cGAS with dsDNA and bound ATP and 2'-dGTP
• Chain: C
• Resolution: 2.23 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	C	T334 K335 T338	T176 K177 T180
BS02	dna	C	R158 L159 K160 R161 H203 K395	R10 L11 K12 R13 H55 K232
BS03	dna	C	R161 S165 A168 N196 Y200 Y201	R13 S17 A20 N48 Y52 Y53
BS04	ATP	C	G198 S199 E211 D213 R364 S368 E371 K402 S420 Y421	G50 S51 E63 D65 R201 S205 E208 K239 S257 Y258
BS05	DGT	C	S291 P292 I309 R364 S366 S368	S133 P134 I151 R201 S203 S205
BS06	MG	C	E211 D213	E63 D65
BS07	ZN	C	H378 C385 C392	H215 C222 C229

External links

• PDB: RCSB:8sj2, PDBe:8sj2, PDBj:8sj2
• PDBsum: 8sj2
• PubMed: 38740774
• UniProt: Q8C6L5|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)