Structure of PDB 8shy Chain C

Receptor sequence
>8shyC (length=359) Species: 10090 (Mus musculus) [Search protein sequence]
GTGPDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVE
QLNTGSYYEHVKISAPNQFNVMFKLEVPRIELQEYYETGAFYLVKFKGNP
LSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLL
IRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYL
VPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKEC
LKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSS
CFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYER
NNGFPIFDK
3D structure
PDB8shy Structure of binary complex of mouse cGAS QN and bound ATP
ChainC
Resolution1.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C H378 C385 C392 H231 C238 C245
BS02 ATP C G198 S199 N213 R364 S368 E371 K402 S420 Y421 G55 S56 N70 R217 S221 E224 K255 S273 Y274
External links
PDB RCSB:8shy, PDBe:8shy, PDBj:8shy
PDBsum8shy
PubMed38740774
UniProtQ8C6L5|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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