Structure of PDB 8sgr Chain C

Receptor sequence
>8sgrC (length=393) Species: 9606 (Homo sapiens) [Search protein sequence]
SLLPVDDAINGLSEEQRQLRQTMAKFLQEHLAPKAQEIDRSNEFKNLREF
WKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAHS
NLCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKA
EKKGNHYILNGNKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKG
MPGFSTSKKLDKLGMRGSNTCELIFEDCKIPAANILGHENKGVYVLMSGL
DLERLVLAGGPLGLMQAVLDHTIPYLHVREAFGQKIGHFQLMQGKMADMY
TRLMACRQYVYNVAKACDEGHCTAKDCAGVILYSAECATQVALDGIQCFG
GNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFH
3D structure
PDB8sgr High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology.
ChainC
Resolution2.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.8.1: short-chain acyl-CoA dehydrogenase.
1.3.8.4: isovaleryl-CoA dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD C S168 G173 S174 W198 T200 L402 G408 T409 L415 S135 G140 S141 W165 T167 L369 G375 T376 L382
BS02 FAD C R312 F315 I319 F322 Q380 C381 G384 R279 F282 I286 F289 Q347 C348 G351
Gene Ontology
Molecular Function
GO:0003995 acyl-CoA dehydrogenase activity
GO:0005515 protein binding
GO:0008470 3-methylbutanoyl-CoA dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0016937 short-chain fatty acyl-CoA dehydrogenase activity
GO:0042802 identical protein binding
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006552 L-leucine catabolic process
GO:0006631 fatty acid metabolic process
GO:0009083 branched-chain amino acid catabolic process
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8sgr, PDBe:8sgr, PDBj:8sgr
PDBsum8sgr
PubMed37839702
UniProtP26440|IVD_HUMAN Isovaleryl-CoA dehydrogenase, mitochondrial (Gene Name=IVD)

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