Structure of PDB 8sgp Chain C

Receptor sequence
>8sgpC (length=385) Species: 9606 (Homo sapiens) [Search protein sequence]
GFSFEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELG
LMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIII
AGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYII
NGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGR
KELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVA
AGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARM
SYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEY
PVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYK
3D structure
PDB8sgp High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology.
ChainC
Resolution2.69 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.8.7: medium-chain acyl-CoA dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD C Y158 T161 G166 S167 W191 T193 I396 T403 Q405 Y123 T126 G131 S132 W156 T158 I361 T368 Q370
BS02 FAD C R306 T308 F309 L313 Q374 I375 G377 G378 R271 T273 F274 L278 Q339 I340 G342 G343
Gene Ontology
Molecular Function
GO:0003995 acyl-CoA dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0042802 identical protein binding
GO:0050660 flavin adenine dinucleotide binding
GO:0070991 medium-chain fatty acyl-CoA dehydrogenase activity
Biological Process
GO:0001889 liver development
GO:0005978 glycogen biosynthetic process
GO:0006082 organic acid metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0007507 heart development
GO:0009409 response to cold
GO:0009437 carnitine metabolic process
GO:0009791 post-embryonic development
GO:0019254 carnitine metabolic process, CoA-linked
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0042594 response to starvation
GO:0045329 carnitine biosynthetic process
GO:0051791 medium-chain fatty acid metabolic process
GO:0051793 medium-chain fatty acid catabolic process
GO:0055007 cardiac muscle cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0030424 axon
GO:0031966 mitochondrial membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8sgp, PDBe:8sgp, PDBj:8sgp
PDBsum8sgp
PubMed37839702
UniProtP11310|ACADM_HUMAN Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (Gene Name=ACADM)

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