Structure of PDB 8s5m Chain C

Receptor sequence

>8s5mC (length=144) Species: 9606 (Homo sapiens) [Search protein sequence]

WWWHLRVQELGLSAPLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILG
MVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQIRLTDTLGRLSHILEMDH
FALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLLNFVAAQERDQK

3D structure

PDB

8s5m Architecture and regulation of filamentous human cystathionine beta-synthase.

Chain

Resolution

4.0 Å

3D
structure

Enzymatic activity

Enzyme Commision number

4.2.1.22: cystathionine beta-synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SAM	C	A14 L16 G35 F36 D37 Q38 A39 V126 T128 D131	A14 L16 G35 F36 D37 Q38 A39 V126 T128 D131

Gene Ontology

	Molecular Function
GO:0004122	cystathionine beta-synthase activity
GO:0005515	protein binding
GO:0016829	lyase activity
GO:0019825	oxygen binding
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0030170	pyridoxal phosphate binding
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0050421	nitrite reductase (NO-forming) activity
GO:0070025	carbon monoxide binding
GO:0070026	nitric oxide binding
GO:0072341	modified amino acid binding
GO:1904047	S-adenosyl-L-methionine binding

	Biological Process
GO:0001958	endochondral ossification
GO:0001974	blood vessel remodeling
GO:0006534	cysteine metabolic process
GO:0006535	cysteine biosynthetic process from serine
GO:0006563	L-serine metabolic process
GO:0006565	L-serine catabolic process
GO:0006801	superoxide metabolic process
GO:0009069	serine family amino acid metabolic process
GO:0010749	regulation of nitric oxide mediated signal transduction
GO:0019343	cysteine biosynthetic process via cystathionine
GO:0019344	cysteine biosynthetic process
GO:0019346	transsulfuration
GO:0019448	L-cysteine catabolic process
GO:0021587	cerebellum morphogenesis
GO:0031667	response to nutrient levels
GO:0042262	DNA protection
GO:0043066	negative regulation of apoptotic process
GO:0043418	homocysteine catabolic process
GO:0044272	sulfur compound biosynthetic process
GO:0050667	homocysteine metabolic process
GO:0051593	response to folic acid
GO:0060135	maternal process involved in female pregnancy
GO:0060351	cartilage development involved in endochondral bone morphogenesis
GO:0070814	hydrogen sulfide biosynthetic process
GO:0071456	cellular response to hypoxia
GO:0097746	blood vessel diameter maintenance

External links

PDB	RCSB:8s5m, PDBe:8s5m, PDBj:8s5m
PDBsum	8s5m
PubMed	38575566
UniProt	P35520\|CBS_HUMAN Cystathionine beta-synthase (Gene Name=CBS)