Structure of PDB 8rq9 Chain C

Receptor sequence

>8rq9C (length=312) Species: 9606 (Homo sapiens) [Search protein sequence]

NFDTSLPTSHTYLGADMEEFHGRTLHDDDSIQVIPVLPQVMMILVPGQTL
PLQLFHPQEVSMVRNLIQNDRTFAVLAYSNVQEREAEFGTTAEIYAYREE
QDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPEAETLMDRIKK
QLREWDEDSLPSNPIDFSYWVAANLPIDDSLRIQLLKIDSAIQRLRCELD
IMNKCTSLCCKQCQETEITTKNEIFSLSREGPMAAYVNPHGYVHEILTVY
KACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQK
FWGLTRSALIPT

3D structure

PDB

8rq9 Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders

Chain

Resolution

2.91 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	A1H2F	C	P352 H378 W380 W386 W400 F402	P239 H265 W267 W273 W287 F289
BS02	ZN	C	C323 C326 C391 C394	C210 C213 C278 C281

External links

PDB	RCSB:8rq9, PDBe:8rq9, PDBj:8rq9
PDBsum	8rq9
PubMed
UniProt	Q96SW2\|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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