Structure of PDB 8rfn Chain C

Receptor sequence

>8rfnC (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]

MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPI
ISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIF
QFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTG
GSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADA
RIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNK
KFGLSVGHHLGKSIPTDNQIKAR

3D structure

PDB

8rfn Structural dynamics and functional cooperativity of human NQO1 by ambient temperature serial crystallography and simulations.

Chain

Resolution

2.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.6.5.2: NAD(P)H dehydrogenase (quinone).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	C	H12 S17 F18 N19 P103 L104 Q105 W106 F107 T148 T149 G150 Y156 R201	H12 S17 F18 N19 P103 L104 Q105 W106 F107 T148 T149 G150 Y156 R201
BS02	FAD	C	Q67 Y68	Q67 Y68

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003955	NAD(P)H dehydrogenase (quinone) activity
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0004784	superoxide dismutase activity
GO:0005515	protein binding
GO:0008753	NADPH dehydrogenase (quinone) activity
GO:0016491	oxidoreductase activity
GO:0042802	identical protein binding
GO:0050136	NADH:ubiquinone reductase (non-electrogenic) activity

	Biological Process
GO:0000209	protein polyubiquitination
GO:0002931	response to ischemia
GO:0006116	NADH oxidation
GO:0006743	ubiquinone metabolic process
GO:0006801	superoxide metabolic process
GO:0006805	xenobiotic metabolic process
GO:0006809	nitric oxide biosynthetic process
GO:0006979	response to oxidative stress
GO:0007271	synaptic transmission, cholinergic
GO:0007584	response to nutrient
GO:0009410	response to xenobiotic stimulus
GO:0009636	response to toxic substance
GO:0009725	response to hormone
GO:0009743	response to carbohydrate
GO:0014070	response to organic cyclic compound
GO:0014075	response to amine
GO:0019430	removal of superoxide radicals
GO:0030163	protein catabolic process
GO:0032355	response to estradiol
GO:0032496	response to lipopolysaccharide
GO:0033574	response to testosterone
GO:0034599	cellular response to oxidative stress
GO:0042177	negative regulation of protein catabolic process
GO:0042360	vitamin E metabolic process
GO:0042373	vitamin K metabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043279	response to alkaloid
GO:0043525	positive regulation of neuron apoptotic process
GO:0045087	innate immune response
GO:0045454	cell redox homeostasis
GO:0045471	response to ethanol
GO:0051602	response to electrical stimulus
GO:0070301	cellular response to hydrogen peroxide
GO:0070995	NADPH oxidation
GO:0071248	cellular response to metal ion
GO:0110076	negative regulation of ferroptosis
GO:1904772	response to tetrachloromethane
GO:1904844	response to L-glutamine
GO:1904880	response to hydrogen sulfide
GO:1905395	response to flavonoid

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0045202	synapse

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8rfn, PDBe:8rfn, PDBj:8rfn
PDBsum	8rfn
PubMed	38501509
UniProt	P15559\|NQO1_HUMAN NAD(P)H dehydrogenase [quinone] 1 (Gene Name=NQO1)

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