Structure of PDB 8r3p Chain C

Receptor sequence

>8r3pC (length=668) Species: 1352 (Enterococcus faecium)

MFDKIDQLGVNTIRTLSIEAVQKANSGHPGLPMGAAPMAYALWTKHLKVN
PTTSKNWADRDRFVLSAGHGSAMLYSLLHLAGYQVTIDDLKQFRQWDSKT
PGHPEVHHTDGVEATTGPLGQGIAMAVGMAMAEAHLAATYNKENFNVMDH
YTYAICGDGDLMEGVSQEASSMAGHMKLGKLIVLYDSNDISLDGPTSKAF
TENVGARYEAYGWQHILVKDGNDLEAISKAIEEAKAETDKPTLIEVKTVI
GYGAPKEGTSAVHGAPLGEDGIKMAKEVYGWEYPDFTVPEEVAARFHQTM
IEEGQKAEDAWNEMFANYKKAYPELAQQFEDAFDGKLPENWDAELPTYEV
GSSQASRVSSKEVIQELSKAIPSFWGGSADLSGSNNTMVAADKDFTPEHY
EGRNIWFGVREFAMASAMNGIQLHGGTRIYGGTFFVFVDYLRPAVRLAAI
QHTPVVYVLTHDSVAVGEDGPTHEPIEQLASVRCMPGVQVIRPADGNETR
AAWKVAMETTDAPTILVLSRQNLPVLPSTKEVADEMVKKGAYVLSPSQGE
TPEGILIATGSEVDLAVKAQKELAEKGKDVSVVSMPSFDLFEKQSSEYKE
SVLPKSVKKRVAIEAAASFGWERYVGTEGATITIDHFGASAPGTKILEEF
GFTVENVVNTYNQLSENL

3D structure

• PDB: 8r3p Are Transketolases relevant Targets fighting Human Pathogens? A comparative Biochemical, Bioinformatic and Structural Study
• Chain: C
• Resolution: 2.9 Å

Enzymatic activity

• Enzyme Commision number: 2.2.1.1: transketolase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TPP	C	H69 L119 G157 D158 G159 N188 I190 L192 H263	H69 L119 G157 D158 G159 N188 I190 L192 H263
BS02	MG	C	G157 D158 D186 N188	G157 D158 D186 N188
BS03	TPP	C	F437 Y440 H473	F437 Y440 H473

Gene Ontology

Molecular Function

• GO:0004802 transketolase activity
• GO:0016740 transferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006098 pentose-phosphate shunt

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:8r3p, PDBe:8r3p, PDBj:8r3p
• PDBsum: 8r3p
• UniProt: A0A133CKH8