Structure of PDB 8r23 Chain C

Receptor sequence
>8r23C (length=429) Species: 9606 (Homo sapiens) [Search protein sequence]
PEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYI
TQNGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICP
ILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIK
AYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLI
TESTYATTIRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETF
WERMNLKVPIYFSTGLTEKANHYYKLFIPWTEFKHIKAFDRAFADNPGPM
VVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRK
LEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKK
MEFLKQKIEQELRVNCYMPANGETVTLPT
3D structure
PDB8r23 Assembly mechanism of Integrator's RNA cleavage module.
ChainC
Resolution3.2 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C H68 H70 H157 D178 H67 H69 H156 D177
BS02 ZN C D72 H73 H414 D71 H72 H395
Gene Ontology
Molecular Function
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0016180 snRNA processing
GO:0034243 regulation of transcription elongation by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032039 integrator complex
GO:0072562 blood microparticle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8r23, PDBe:8r23, PDBj:8r23
PDBsum8r23
PubMed39032489
UniProtQ5TA45|INT11_HUMAN Integrator complex subunit 11 (Gene Name=INTS11)

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