Structure of PDB 8qjf Chain C

Receptor sequence

>8qjfC (length=196) Species: 9606 (Homo sapiens) [Search protein sequence]

MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSS
FICNTLQPGCNSVCYDQFFPISHVRLWSLQLILVSTPALLVAMHVAHQQH
IEKKMISGTLWWTYVISVVFRLLFEAVFMYVFYLLYPGYAMVRLVKCDVY
PCPNTVDCFVSRPTEKTVFTVFMLAASGICIILNVAEVVYLIIRAC

3D structure

PDB

8qjf Two distinct mechanisms of connexin channel inhibition by mefloquine and 2-aminoethoxydiphenyl borate

Chain

Resolution

2.86 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CLR	C	L9 S85	L9 S85
BS02	CLR	C	M1 W3 L6	M1 W3 L6

External links

PDB	RCSB:8qjf, PDBe:8qjf, PDBj:8qjf
PDBsum	8qjf
PubMed
UniProt	P08034\|CXB1_HUMAN Gap junction beta-1 protein (Gene Name=GJB1)

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