Structure of PDB 8qhq Chain C

Receptor sequence
>8qhqC (length=143) Species: 9606 (Homo sapiens) [Search protein sequence]
MGRPALYFCGSIRGGREDRTLYERIVSRLRRFGTVLTEHVAAAELGARGE
AGGDRLIHEQDLEWLQQADVVVAEVTQPSLGVGYQLGRAVAFNKRILCLF
RPQSGRVLSAMIRGAADGSRFQVWDYEEGEVEALLDRYFEADP
3D structure
PDB8qhq Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1.
ChainC
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5HU C C26 G27 S28 I29 R30 I76 S98 G100 Q104 C9 G10 S11 I12 R13 I57 S79 G81 Q85
BS02 5HU C S128 A129 M130 S109 A110 M111
Gene Ontology
Molecular Function
GO:0070694 deoxyribonucleoside 5'-monophosphate N-glycosidase activity
Biological Process
GO:0009159 deoxyribonucleoside monophosphate catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8qhq, PDBe:8qhq, PDBj:8qhq
PDBsum8qhq
PubMed37884503
UniProtO43598|DNPH1_HUMAN 5-hydroxymethyl-dUMP N-hydrolase (Gene Name=DNPH1)

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