Structure of PDB 8pec Chain C

Receptor sequence
>8pecC (length=227) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
EWQENKSWNVHFTEHKSQGVVVLWNENEQQGFTNNLKRANQAFLPASTLK
IPNSLIALDLGVVKDEHQVFKWDGQTRDIATWNRDHNLITAMKYSVVPVY
QEFARQIGEARMSKMLHAFDYGNIRISATEQISFLRKLYHNKLHVSERSQ
RIVKQAMLTEANGDYIIRAKTGYAARIEPKIGWWVGWVELDDNVWFFAMN
MDMPTSDGLGLRQAITKEVLKQEKIIP
3D structure
PDB8pec Epistasis Arises from Shifting the Rate-Limiting Step during Enzyme Evolution.
ChainC
Resolution2.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CTJ C A69 S70 S118 T209 Y211 A212 A213 R250 A46 S47 S95 T171 Y173 A174 A175 R212
Gene Ontology
Molecular Function
GO:0008658 penicillin binding
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0046677 response to antibiotic
GO:0071555 cell wall organization

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8pec, PDBe:8pec, PDBj:8pec
PDBsum8pec
PubMed38828429
UniProtQ6XEC0

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