Structure of PDB 8p7c Chain C

Receptor sequence
>8p7cC (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
TLVSDFKQQKLEQEAQKNWDLFYKRNSTNFFKDRHWTTREFEELRSQKLT
MLEAGCGVGNCLFPLLEEDPNIFAYACDFSPRAIEYVKQNPLYDTERCKV
FQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLKPG
KSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQLFM
DTGYEEVVNEYVFRETVNKKEGLCVPRVFLQSKFLKPPK
3D structure
PDB8p7c Structural basis of the cooperation between the m3C-RNA-methyltransferase METTL6 with SerRS amino-acyl-synthetase for tRNA recognition
ChainC
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna C K43 D46 L47 K50 F56 F57 K58 R60 H61 W62 R114 Y190 H195 R199 R213 Q214 N250 K252 R259 K17 D20 L21 K24 F30 F31 K32 R34 H35 W36 R82 Y158 H163 R167 R181 Q182 N218 K220 R227
BS02 SAH C W45 Y49 R60 G87 C93 D110 F111 L137 I157 W19 Y23 R34 G55 C61 D78 F79 L105 I125
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008173 RNA methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0019899 enzyme binding
GO:0052735 tRNA (cytidine-3-)-methyltransferase activity
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
GO:0032259 methylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8p7c, PDBe:8p7c, PDBj:8p7c
PDBsum8p7c
PubMed38918637
UniProtQ8TCB7|METL6_HUMAN tRNA N(3)-methylcytidine methyltransferase METTL6 (Gene Name=METTL6)

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