Structure of PDB 8p4h Chain C

Receptor sequence
>8p4hC (length=376) Species: 9606 (Homo sapiens) [Search protein sequence]
EEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTG
MILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQ
SPDIARNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRR
NGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMR
DALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVD
TYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVS
YAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKP
IYQRTAAYGHFGRDSFPWEVPKKLKY
3D structure
PDB8p4h Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening.
ChainC
Resolution1.71 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.6: methionine adenosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UM6 C F18 F20 Q190 W274 R313 F5 F7 Q171 W255 R294
BS02 SAM C A55 Q113 I117 D134 A42 Q100 I104 D115
BS03 UM6 C A276 L315 Q317 S331 I332 F333 A257 L296 Q298 S312 I313 F314
Gene Ontology
Molecular Function
GO:0004478 methionine adenosyltransferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0036094 small molecule binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006556 S-adenosylmethionine biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0034214 protein hexamerization
GO:0051291 protein heterooligomerization
GO:0061431 cellular response to methionine
GO:1904263 positive regulation of TORC1 signaling
GO:1990830 cellular response to leukemia inhibitory factor
Cellular Component
GO:0005829 cytosol
GO:0048269 methionine adenosyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8p4h, PDBe:8p4h, PDBj:8p4h
PDBsum8p4h
PubMed37591318
UniProtP31153|METK2_HUMAN S-adenosylmethionine synthase isoform type-2 (Gene Name=MAT2A)

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