Structure of PDB 8p2z Chain C

Receptor sequence
>8p2zC (length=573) Species: 9606 (Homo sapiens) [Search protein sequence]
NSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLL
YLELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWA
FWYLFHSFQDPLPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPS
LQENGGVQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLII
YLIRGLTLHGATNGLMYMFTPKIEQLANPKAWINAATQIFFSLGLGFGSL
IAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKATFNYENC
LKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCS
LESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLG
NTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDI
FNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMW
AGVSPLLIVSLFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVI
GLLVASSTMCIPLAALGTFVQRR
3D structure
PDB8p2z Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2
ChainC
Resolution3.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C W111 F114 H115 F117 L172 L176 L179 L183 R187 W102 F105 H106 F108 L163 L167 L170 L174 R178
BS02 YCP C Y21 A22 G24 L25 G26 Y102 F250 F256 Y12 A13 G15 L16 G17 Y93 F241 F247
Gene Ontology
Molecular Function
GO:0005298 proline:sodium symporter activity
GO:0005515 protein binding
GO:0015171 amino acid transmembrane transporter activity
GO:0015175 neutral L-amino acid transmembrane transporter activity
GO:0015188 L-isoleucine transmembrane transporter activity
GO:0015193 L-proline transmembrane transporter activity
GO:0015199 amino-acid betaine transmembrane transporter activity
GO:0015293 symporter activity
GO:0015370 solute:sodium symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006865 amino acid transport
GO:0015816 glycine transport
GO:0015824 proline transport
GO:0015838 amino-acid betaine transport
GO:0035725 sodium ion transmembrane transport
GO:0089718 amino acid import across plasma membrane
GO:0150104 transport across blood-brain barrier
GO:1903804 glycine import across plasma membrane
GO:1903806 L-isoleucine import across plasma membrane
GO:1904271 L-proline import across plasma membrane
GO:1905647 proline import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016324 apical plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8p2z, PDBe:8p2z, PDBj:8p2z
PDBsum8p2z
PubMed38951531
UniProtQ9NP91|S6A20_HUMAN Sodium- and chloride-dependent transporter XTRP3 (Gene Name=SLC6A20)

[Back to BioLiP]