Structure of PDB 8oj5 Chain C

Receptor sequence
>8oj5C (length=188) Species: 9606 (Homo sapiens) [Search protein sequence]
IGAKKLRKLEEKQARKAQREAEEAEREERKRLESQREAEWKKEEERLRLE
EEQKEEEERKAREEQAQREHEEYLKLKEAFVVEEEGVGETMTEEQSQSFL
TEFINYIKQSKVVLLEDLASQVGLRTQDTINRIQDLLAEGTITGVIDDRG
KFIYITPEELAAVANFIRQRGRVSIAELAQASNSLIAW
3D structure
PDB8oj5 UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER
ChainC
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 rna C G118 A119 K120 K121 K124 R131 R135 G2 A3 K4 K5 K8 R15 R19
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
GO:0141185 UFM1-modified protein reader activity
Biological Process
GO:0008284 positive regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0030335 positive regulation of cell migration
GO:0031647 regulation of protein stability
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032790 ribosome disassembly
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0034976 response to endoplasmic reticulum stress
GO:0043066 negative regulation of apoptotic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051216 cartilage development
GO:0061709 reticulophagy
GO:0070972 protein localization to endoplasmic reticulum
GO:0071569 protein ufmylation
GO:0072344 rescue of stalled ribosome
GO:0140501 positive regulation of reticulophagy
GO:1900100 positive regulation of plasma cell differentiation
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1902808 positive regulation of cell cycle G1/S phase transition
GO:1903052 positive regulation of proteolysis involved in protein catabolic process
GO:1903721 positive regulation of I-kappaB phosphorylation
GO:1903895 negative regulation of IRE1-mediated unfolded protein response
GO:1903898 negative regulation of PERK-mediated unfolded protein response
GO:1905050 positive regulation of metallopeptidase activity
GO:1905552 positive regulation of protein localization to endoplasmic reticulum
GO:1905636 positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
GO:1990592 protein K69-linked ufmylation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:8oj5, PDBe:8oj5, PDBj:8oj5
PDBsum8oj5
PubMed38383785
UniProtQ96HY6|DDRGK_HUMAN DDRGK domain-containing protein 1 (Gene Name=DDRGK1)

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