Structure of PDB 8of2 Chain C

Receptor sequence
>8of2C (length=251) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]
EAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKE
RSNTAVVCQADLTNSNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTP
LVQKTVETQVAELIGTNAIAPFLLTMSFAQRQTSSNLSIVNLCDAMVDQP
CMAFSLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPVAMGEEE
KDKWRRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKVDGGLSLVH
A
3D structure
PDB8of2 The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents.
ChainC
Resolution1.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.33: pteridine reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP C R14 I15 H33 Y34 H35 N36 S37 D62 L63 N93 S95 T126 L159 K178 P204 S207 L208 R13 I14 H32 Y33 H34 N35 S36 D61 L62 N92 S94 T116 L142 K161 P187 S190 L191
BS02 3AY C S95 F97 Y174 S94 F96 Y157
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:8of2, PDBe:8of2, PDBj:8of2
PDBsum8of2
PubMed38043491
UniProtQ581W1

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