Structure of PDB 8kg5 Chain C

Receptor sequence
>8kg5C (length=449) Species: 10665,11259 [Search protein sequence]
QNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAK
VKLIKQELDKYKNAVTELQLLMFLGFLLGVGSAIASGVAVCKVLHLEGEV
NKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSI
SNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDM
PITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCW
KLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNR
VFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIV
SCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEG
KSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELL
3D structure
PDB8kg5 Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein.
ChainC
Resolution3.17 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 336 C F140 F488 F76 F424
BS02 336 C F137 L138 G139 F140 E356 M396 D486 F488 F73 L74 G75 F76 E292 M332 D422 F424
External links
PDB RCSB:8kg5, PDBe:8kg5, PDBj:8kg5
PDBsum8kg5
PubMed38853183
UniProtP03420|FUS_HRSVA Fusion glycoprotein F0 (Gene Name=F);
P10104

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